藥物交互作用
Adenovirus types 4 and 7 live + Cyclophosphamide
嚴重程度: 嚴重
Adenovirus types 4 and 7 live and Cyclophosphamide: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
用白話說明這項交互作用的意義
Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Cytotoxic immunosuppression impairs vaccine immune response and permits replication of the live attenuated virus.
處置方式
Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclophosphamide 的其他交互作用
常見問題
Can I take Adenovirus types 4 and 7 live with Cyclophosphamide?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclophosphamide suppresses immune function, which can blunt the response to the vaccine. Because the vaccine contains live virus, an immunosuppressed patient may develop disseminated vaccine-strain infection.
How serious is the interaction between Adenovirus types 4 and 7 live and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during cyclophosphamide therapy and for at least 3 months after it ends. Choose a non-live alternative where one is available.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Belatacept, Bendamustine, Busulfan. The full list is on the Cyclophosphamide page.
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