藥物交互作用
Busulfan + Cyclophosphamide
嚴重程度: 嚴重
Busulfan and Cyclophosphamide: major interaction.
最後更新
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摘要
Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
用白話說明這項交互作用的意義
Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Busulfan belongs to Oncology; Cyclophosphamide belongs to Oncology.
為什麼會發生
Additive myelosuppression, with busulfan depleting glutathione and competing for hepatic metabolism of cyclophosphamide.
處置方式
Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclophosphamide 的其他交互作用
Busulfan 的其他交互作用
常見問題
Can I take Busulfan with Cyclophosphamide?
MediHelp rates the interaction as major. Busulfan and Cyclophosphamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are myelosuppressive alkylators, and together they markedly increase marrow toxicity. Busulfan given shortly before cyclophosphamide may also alter cyclophosphamide metabolism and increase hepatic toxicity such as veno-occlusive disease.
How serious is the interaction between Busulfan and Cyclophosphamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only in planned regimens with established sequencing and doses, and monitor blood counts and liver function closely. Allow an interval between busulfan and cyclophosphamide as specified in the protocol.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
