藥物交互作用
Cyclophosphamide + Deferiprone
嚴重程度: 嚴重
Cyclophosphamide and Deferiprone: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Deferiprone can cause neutropenia and agranulocytosis, and cyclophosphamide is itself myelosuppressive. Combined use increases the risk of severe, potentially fatal infections.
用白話說明這項交互作用的意義
Cyclophosphamide and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Deferiprone belongs to Miscellaneous.
為什麼會發生
Additive bone marrow suppression with pharmacodynamic synergy on neutrophil depletion.
處置方式
Avoid the combination if possible. If necessary, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia develops.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclophosphamide 的其他交互作用
Deferiprone 的其他交互作用
常見問題
Can I take Cyclophosphamide with Deferiprone?
MediHelp rates the interaction as major. Cyclophosphamide and Deferiprone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and cyclophosphamide is itself myelosuppressive. Combined use increases the risk of severe, potentially fatal infections.
How serious is the interaction between Cyclophosphamide and Deferiprone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor the absolute neutrophil count more frequently and interrupt deferiprone if neutropenia develops.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
