藥物交互作用
Allopurinol + Amlodipine-benazepril
嚴重程度: 中度
Allopurinol and Amlodipine-benazepril: moderate interaction.
最後更新
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摘要
Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.
用白話說明這項交互作用的意義
Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Amlodipine-benazepril belongs to Cardiovascular.
為什麼會發生
The mechanism is not established; an additive predisposition to hypersensitivity has been proposed.
處置方式
Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-benazepril 的其他交互作用
Allopurinol 的其他交互作用
常見問題
Can I take Allopurinol with Amlodipine-benazepril?
MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-benazepril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Case reports suggest ACE inhibitors given with allopurinol may increase the risk of hypersensitivity reactions, including serious skin reactions. The evidence is limited, but the reactions can be severe.
How serious is the interaction between Allopurinol and Amlodipine-benazepril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, fever and other hypersensitivity signs, especially early in therapy and in renal impairment. Stop allopurinol promptly if a rash appears.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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