藥物交互作用
Allopurinol + Amlodipine-perindopril
嚴重程度: 中度
Allopurinol and Amlodipine-perindopril: moderate interaction.
最後更新
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摘要
ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
用白話說明這項交互作用的意義
Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Allopurinol belongs to Genitourinary; Amlodipine-perindopril belongs to Cardiovascular.
為什麼會發生
The mechanism is not established; an additive hypersensitivity or immune-mediated effect has been proposed.
處置方式
Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Amlodipine-perindopril 的其他交互作用
Allopurinol 的其他交互作用
常見問題
Can I take Allopurinol with Amlodipine-perindopril?
MediHelp rates the interaction as moderate. Allopurinol and Amlodipine-perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors given with allopurinol have been associated with hypersensitivity reactions, including rare severe skin reactions. The evidence is limited to case reports and the mechanism is unclear.
How serious is the interaction between Allopurinol and Amlodipine-perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report rash, fever or mucosal lesions promptly and stop allopurinol if these occur. Monitor renal function, as allopurinol dose may need adjustment.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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