藥物交互作用
Alogliptin-metformin + Dalfampridine
嚴重程度: 中度
Alogliptin-metformin and Dalfampridine: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both metformin and dalfampridine are eliminated through renal cation transport, so competition could raise exposure to either drug. Increased dalfampridine levels raise seizure risk, so this is of concern in patients with reduced renal function.
用白話說明這項交互作用的意義
Alogliptin-metformin and Dalfampridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Dalfampridine belongs to Central Nervous System.
為什麼會發生
Competition for OCT2-mediated renal tubular secretion.
處置方式
Check renal function before and during combined use and monitor for metformin adverse effects and neurological symptoms; avoid dalfampridine if renal function is impaired.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Alogliptin-metformin 的其他交互作用
Dalfampridine 的其他交互作用
常見問題
Can I take Alogliptin-metformin with Dalfampridine?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Dalfampridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are eliminated through renal cation transport, so competition could raise exposure to either drug. Increased dalfampridine levels raise seizure risk, so this is of concern in patients with reduced renal function.
How serious is the interaction between Alogliptin-metformin and Dalfampridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check renal function before and during combined use and monitor for metformin adverse effects and neurological symptoms; avoid dalfampridine if renal function is impaired.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
