藥物交互作用
Dalfampridine + Dapagliflozin-metformin
嚴重程度: 中度
Dalfampridine and Dapagliflozin-metformin: moderate interaction.
最後更新
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摘要
Both metformin and dalfampridine are cleared by renal OCT2 secretion, so co-administration could theoretically increase exposure to either drug. Higher dalfampridine levels raise seizure risk, and higher metformin levels raise the risk of adverse effects.
用白話說明這項交互作用的意義
Dalfampridine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalfampridine belongs to Central Nervous System; Dapagliflozin-metformin belongs to Endocrine.
為什麼會發生
Competition for OCT2-mediated renal tubular secretion.
處置方式
Monitor for dalfampridine-related adverse effects including seizures, and for metformin toxicity. Check renal function before and during combined use.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dapagliflozin-metformin 的其他交互作用
Dalfampridine 的其他交互作用
常見問題
Can I take Dalfampridine with Dapagliflozin-metformin?
MediHelp rates the interaction as moderate. Dalfampridine and Dapagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both metformin and dalfampridine are cleared by renal OCT2 secretion, so co-administration could theoretically increase exposure to either drug. Higher dalfampridine levels raise seizure risk, and higher metformin levels raise the risk of adverse effects.
How serious is the interaction between Dalfampridine and Dapagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dalfampridine-related adverse effects including seizures, and for metformin toxicity. Check renal function before and during combined use.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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