藥物交互作用
Dalfampridine + Trilaciclib
嚴重程度: 嚴重
Dalfampridine and Trilaciclib: major interaction.
最後更新
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摘要
Dalfampridine is eliminated largely by active renal secretion through OCT2. Trilaciclib inhibits renal transporters, which may raise dalfampridine levels and increase the risk of seizures, a concentration-dependent toxicity.
用白話說明這項交互作用的意義
Dalfampridine and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalfampridine belongs to Central Nervous System; Trilaciclib belongs to Oncology.
為什麼會發生
Trilaciclib inhibits OCT2 and MATE transporters, reducing renal secretion of dalfampridine.
處置方式
Avoid the combination where possible, and weigh the benefit of trilaciclib against seizure risk. If used together, monitor for neurological symptoms, especially in patients with renal impairment or seizure history.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Dalfampridine 的其他交互作用
Trilaciclib 的其他交互作用
常見問題
Can I take Dalfampridine with Trilaciclib?
MediHelp rates the interaction as major. Dalfampridine and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dalfampridine is eliminated largely by active renal secretion through OCT2. Trilaciclib inhibits renal transporters, which may raise dalfampridine levels and increase the risk of seizures, a concentration-dependent toxicity.
How serious is the interaction between Dalfampridine and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, and weigh the benefit of trilaciclib against seizure risk. If used together, monitor for neurological symptoms, especially in patients with renal impairment or seizure history.
What other medicines interact with Dalfampridine?
MediHelp also lists interactions of Dalfampridine with, for example, Alogliptin-metformin, Canagliflozin-metformin, Dapagliflozin-metformin. The full list is on the Dalfampridine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
