藥物交互作用
Alprazolam + Gabapentin
嚴重程度: 嚴重
Alprazolam and Gabapentin: major interaction.
最後更新 來源: US FDA label
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摘要
Gabapentin combined with alprazolam causes additive sedation and psychomotor impairment. Respiratory depression may occur, especially in older patients, those with lung disease, or at high doses.
用白話說明這項交互作用的意義
Alprazolam and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Gabapentin belongs to Central Nervous System.
為什麼會發生
Additive pharmacodynamic CNS and respiratory depression.
處置方式
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and dose increases. Counsel on alcohol and driving.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Alprazolam 的其他交互作用
Gabapentin 的其他交互作用
常見問題
Can I take Alprazolam with Gabapentin?
MediHelp rates the interaction as major. Alprazolam and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentin combined with alprazolam causes additive sedation and psychomotor impairment. Respiratory depression may occur, especially in older patients, those with lung disease, or at high doses.
How serious is the interaction between Alprazolam and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and dose increases. Counsel on alcohol and driving.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
