藥物交互作用
Buprenorphine buccal + Gabapentin
嚴重程度: 嚴重
Buprenorphine buccal and Gabapentin: major interaction.
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
摘要
Gabapentin combined with an opioid such as buprenorphine can cause profound sedation and respiratory depression. Regulators have warned of this risk, especially in older patients and those with respiratory disease.
用白話說明這項交互作用的意義
Buprenorphine buccal and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive central nervous system and respiratory depression.
處置方式
Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and after dose increases. Consider dose reduction of gabapentin in at-risk patients.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Gabapentin 的其他交互作用
常見問題
Can I take Buprenorphine buccal with Gabapentin?
MediHelp rates the interaction as major. Buprenorphine buccal and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentin combined with an opioid such as buprenorphine can cause profound sedation and respiratory depression. Regulators have warned of this risk, especially in older patients and those with respiratory disease.
How serious is the interaction between Buprenorphine buccal and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, particularly at initiation and after dose increases. Consider dose reduction of gabapentin in at-risk patients.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
