藥物交互作用
Benzhydrocodone / acetaminophen + Gabapentin
嚴重程度: 嚴重
Benzhydrocodone / acetaminophen and Gabapentin: major interaction.
最後更新 來源: US FDA label
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摘要
Opioids combined with gabapentinoids carry an increased risk of profound sedation, respiratory depression, coma and death. Regulators have issued warnings about this because gabapentin can potentiate opioid-induced respiratory depression.
用白話說明這項交互作用的意義
Benzhydrocodone / acetaminophen and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
為什麼會發生
Additive CNS and respiratory depression, and gabapentin may also raise opioid effect.
處置方式
Reserve the combination for patients with inadequate alternatives, using the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression, especially in older patients and those with lung disease or renal impairment.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Gabapentin 的其他交互作用
常見問題
Can I take Benzhydrocodone / acetaminophen with Gabapentin?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Gabapentin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with gabapentinoids carry an increased risk of profound sedation, respiratory depression, coma and death. Regulators have issued warnings about this because gabapentin can potentiate opioid-induced respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Gabapentin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with inadequate alternatives, using the lowest effective doses and shortest duration. Monitor for sedation and respiratory depression, especially in older patients and those with lung disease or renal impairment.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
