藥物交互作用
Alprazolam + Oliceridine
嚴重程度: 嚴重
Alprazolam and Oliceridine: major interaction.
最後更新 來源: US FDA label
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本頁的臨床內容僅提供英文版。
摘要
Combining an opioid with a benzodiazepine produces additive central nervous system and respiratory depression. Profound sedation, respiratory failure, coma and death can result.
用白話說明這項交互作用的意義
Alprazolam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
為什麼會發生
Additive pharmacodynamic CNS and respiratory depression via opioid and GABA-A receptor effects.
處置方式
Reserve combined use for patients without adequate alternatives, using the lowest effective doses and shortest duration. Monitor closely for sedation and respiratory depression.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Alprazolam 的其他交互作用
Oliceridine 的其他交互作用
常見問題
Can I take Alprazolam with Oliceridine?
MediHelp rates the interaction as major. Alprazolam and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a benzodiazepine produces additive central nervous system and respiratory depression. Profound sedation, respiratory failure, coma and death can result.
How serious is the interaction between Alprazolam and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients without adequate alternatives, using the lowest effective doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
