藥品參考
Oliceridine
Oliceridine is a medicine in the class musculoskeletal. It is used for pain management.
- 藥物類別: Musculoskeletal
- 用途: pain management
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Musculoskeletal
- 常見劑型
- 注射劑
- 已知交互作用
- 200 (禁忌併用: 1 · 嚴重: 98 · 中度: 78 · 輕微: 23)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Oliceridine is a full opioid agonist, relatively selective for the mu-opioid receptor; its principal therapeutic action is analgesia, with no ceiling effect to analgesia.
成人常用劑量（仿單摘要）
Acute pain severe enough to require an IV opioid: initial dose 1.5 mg IV given by a healthcare provider; supplemental doses of 0.75 mg beginning 1 hour after the initial dose and hourly thereafter as needed; single doses greater than 3 mg not to be given; maximum cumulative daily dose 27 mg.
懷孕與哺乳
- 懷孕
- Unsafe Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor.
- 哺乳
- Unknown It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
已通報的副作用
- Nausea
- Vomiting
- Dizziness
- Headache
- Constipation
- Pruritus
黑框警語
- Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly. Serious, life-threatening or fatal respiratory depression may occur, especially during initiation or after a dosage increase. Concomitant use with benzodiazepines or other CNS depressants, including alcohol, may cause profound sedation, respiratory depression, coma and death; reserve for patients with inadequate alternatives. Prolonged use in pregnancy can cause neonatal opioid withdrawal syndrome, which may be life-threatening.
禁忌症
- Significant respiratory depression
- Acute or severe bronchial asthma in an unmonitored setting or without resuscitative equipment
- Known or suspected gastrointestinal obstruction, including paralytic ileus
哪些人需要特別留意
- QTc prolongation risk with cumulative daily doses above 27 mg; do not exceed 27 mg.
- Increased oliceridine exposure with decreased CYP2D6 function or with CYP3A4 inhibitors (or stopping CYP3A4 inducers) can prolong adverse reactions and worsen respiratory depression.
- Opioid-induced hyperalgesia and allodynia may occur; consider dose reduction or opioid rotation if suspected.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (200)
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
- Aripiprazole + Oliceridine Major
- Asenapine + Oliceridine Major
- Baclofen + Oliceridine Major
- Brexpiprazole + Oliceridine Major
Pro+ 會員專屬
解鎖完整頁面
建立帳號並開始 Pro+ 試用，即可開啟 Oliceridine 的完整藥品專論：劑量、懷孕與哺乳、副作用、警示及所有交互作用。
- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- Patient counselling points
- Food interactions
在網頁版免費試用 Pro+ 7 天，無需信用卡。
同類別的其他藥品
常見問題
What is Oliceridine used for?
Oliceridine is a medicine in the class musculoskeletal. It is used for Pain management.
What side effects have been reported with Oliceridine?
Nausea, Vomiting, Dizziness, Headache, Constipation, Pruritus. Serious warning: Exposes users to risks of opioid addiction, abuse and misuse, which can lead to overdose and death; assess risk before prescribing and reassess regularly.
Can Oliceridine be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Prolonged use in pregnancy may cause neonatal opioid withdrawal syndrome; no human data on birth defects. Animal studies showed reduced live litter size and increased pup mortality. Not recommended during and immediately before labor. Breastfeeding: Unknown. It is not known whether oliceridine is in human milk; weigh the benefits of breastfeeding against the mother's need. Monitor exposed infants for excess sedation and respiratory depression.
What does Oliceridine interact with?
MediHelp lists 200 known interactions for Oliceridine. Contraindicated: 1 · Major: 98 · Moderate: 78 · Minor: 23. The most serious include Isocarboxazid, Alprazolam, Amiodarone.
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