藥物交互作用
Amobarbital + Oliceridine
嚴重程度: 嚴重
Amobarbital and Oliceridine: major interaction.
最後更新 來源: US FDA label
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摘要
Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
用白話說明這項交互作用的意義
Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression plus CYP3A4 induction that increases oliceridine metabolism.
處置方式
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Amobarbital 的其他交互作用
Oliceridine 的其他交互作用
常見問題
Can I take Amobarbital with Oliceridine?
MediHelp rates the interaction as major. Amobarbital and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an opioid with a barbiturate can cause profound sedation, respiratory depression, coma and death. Amobarbital also induces CYP3A4 and may lower oliceridine exposure, reducing analgesia, with risk of toxicity if the inducer is stopped.
How serious is the interaction between Amobarbital and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration with continuous respiratory and sedation monitoring. Titrate oliceridine to effect and reduce the dose with monitoring if amobarbital is discontinued.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
