藥物交互作用
Alprazolam + Sufentanil
嚴重程度: 嚴重
Alprazolam and Sufentanil: major interaction.
最後更新 來源: US FDA label
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摘要
Combining a benzodiazepine with a potent opioid like sufentanil can cause profound sedation, respiratory depression, coma and death. Regulators warn specifically about this class combination.
用白話說明這項交互作用的意義
Alprazolam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alprazolam belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression from opioid receptor agonism and GABA-A modulation.
處置方式
Reserve for situations without alternatives, using the lowest doses and monitoring continuously for respiratory depression and sedation. Ensure resuscitation equipment and naloxone are available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Alprazolam 的其他交互作用
Sufentanil 的其他交互作用
常見問題
Can I take Alprazolam with Sufentanil?
MediHelp rates the interaction as major. Alprazolam and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with a potent opioid like sufentanil can cause profound sedation, respiratory depression, coma and death. Regulators warn specifically about this class combination.
How serious is the interaction between Alprazolam and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for situations without alternatives, using the lowest doses and monitoring continuously for respiratory depression and sedation. Ensure resuscitation equipment and naloxone are available.
What other medicines interact with Alprazolam?
MediHelp also lists interactions of Alprazolam with, for example, Calcium / magnesium / potassium / sodium oxybates, Itraconazole, Ketoconazole. The full list is on the Alprazolam page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
