藥物交互作用
Amobarbital + Sufentanil
嚴重程度: 嚴重
Amobarbital and Sufentanil: major interaction.
最後更新 來源: US FDA label
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摘要
Barbiturates and opioids both depress the CNS and respiration, and combined use can cause profound sedation, respiratory depression, coma or death. Sufentanil is very potent, so the risk is substantial.
用白話說明這項交互作用的意義
Amobarbital and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression through opioid and GABAergic pathways.
處置方式
Use only where monitored, with reduced doses and continuous assessment of respiratory rate and sedation. Have airway support and naloxone available.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Amobarbital 的其他交互作用
Sufentanil 的其他交互作用
常見問題
Can I take Amobarbital with Sufentanil?
MediHelp rates the interaction as major. Amobarbital and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and opioids both depress the CNS and respiration, and combined use can cause profound sedation, respiratory depression, coma or death. Sufentanil is very potent, so the risk is substantial.
How serious is the interaction between Amobarbital and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where monitored, with reduced doses and continuous assessment of respiratory rate and sedation. Have airway support and naloxone available.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
