藥物交互作用
Aripiprazole + Sufentanil
嚴重程度: 嚴重
Aripiprazole and Sufentanil: major interaction.
最後更新 來源: UK SmPC
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摘要
Opioids combined with other CNS depressants increase the risk of profound sedation, respiratory depression and hypotension. Aripiprazole has milder sedative effects but contributes to additive depression.
用白話說明這項交互作用的意義
Aripiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aripiprazole belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
為什麼會發生
Additive CNS and respiratory depression, with additive hypotensive effects.
處置方式
Use the lowest effective sufentanil dose and monitor respiratory rate, sedation and blood pressure. Ensure appropriate monitoring and resuscitation capability in procedural settings.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
- Abilify 1 mg/mL Oral Solution - SmPC sections 4.3/4.5 (class statement: other CNS medicinal products with overlapping adverse reactions such as sedation; "caution should be used when aripiprazole is administered in combination with alcohol or other CNS medicinal products with overlapping adverse re… — electronic medicines compendium (UK SmPC)
Aripiprazole 的其他交互作用
Sufentanil 的其他交互作用
常見問題
Can I take Aripiprazole with Sufentanil?
MediHelp rates the interaction as major. Aripiprazole and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants increase the risk of profound sedation, respiratory depression and hypotension. Aripiprazole has milder sedative effects but contributes to additive depression.
How serious is the interaction between Aripiprazole and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sufentanil dose and monitor respiratory rate, sedation and blood pressure. Ensure appropriate monitoring and resuscitation capability in procedural settings.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
