藥物交互作用
Aluminum hydroxide + Pamidronate
嚴重程度: 中度
Aluminum hydroxide and Pamidronate: moderate interaction.
最後更新
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摘要
Oral pamidronate is poorly absorbed, and polyvalent cations such as aluminum bind bisphosphonates in the gut, reducing absorption further. This could reduce efficacy of oral therapy. Intravenous pamidronate is not affected.
用白話說明這項交互作用的意義
Aluminum hydroxide and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aluminum hydroxide belongs to Gastrointestinal Tract; Pamidronate belongs to Musculoskeletal.
為什麼會發生
Aluminum ions chelate the bisphosphonate in the gastrointestinal lumen, forming poorly absorbed complexes.
處置方式
Separate oral pamidronate from aluminum antacids by at least 2 hours, preferably longer. Use intravenous administration if separation is not feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Aluminum hydroxide 的其他交互作用
Pamidronate 的其他交互作用
常見問題
Can I take Aluminum hydroxide with Pamidronate?
MediHelp rates the interaction as moderate. Aluminum hydroxide and Pamidronate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral pamidronate is poorly absorbed, and polyvalent cations such as aluminum bind bisphosphonates in the gut, reducing absorption further. This could reduce efficacy of oral therapy. Intravenous pamidronate is not affected.
How serious is the interaction between Aluminum hydroxide and Pamidronate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral pamidronate from aluminum antacids by at least 2 hours, preferably longer. Use intravenous administration if separation is not feasible.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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