藥物交互作用
Aluminum hydroxide + Rilpivirine
嚴重程度: 嚴重
Aluminum hydroxide and Rilpivirine: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
用白話說明這項交互作用的意義
Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aluminum hydroxide belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
為什麼會發生
Elevated gastric pH reduces rilpivirine solubility and oral absorption.
處置方式
Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aluminum hydroxide 的其他交互作用
Rilpivirine 的其他交互作用
常見問題
Can I take Aluminum hydroxide with Rilpivirine?
MediHelp rates the interaction as major. Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
How serious is the interaction between Aluminum hydroxide and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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