藥品參考
Pamidronate
Pamidronate is a medicine in the class musculoskeletal. It is used for hypercalcemia of malignancy.
- 藥物類別: Musculoskeletal
- 用途: hypercalcemia of malignancy
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Musculoskeletal
- 常見劑型
- 注射劑
- 常見規格
- 15 mg
- 已知交互作用
- 9 (中度: 5 · 輕微: 4)
- 商品名
- 1
- 國家與市場
- 1
用途
作用方式
Bisphosphonate which inhibits bone resorption via actions on osteoclast activity, leading to an indirect increase in bone density
成人常用劑量（仿單摘要）
Hypercalcemia of Malignancy (Moderate hypercalcemia) (ie, corrected serum calcium 12-13.5 mg/dL): 60-90 mg single-dose IV infusion over 2-24 hours
懷孕與哺乳
- 懷孕
- Unsafe No human data on fetal risk. Bisphosphonates enter bone and are released over years; in animals pamidronate caused bone mineralisation defects and embryo-fetal effects. UK label: do not use at any stage of pregnancy unless life-threatening hypercalcaemia cannot be controlled otherwise.
- 哺乳
- Unknown Very low milk levels after a 30 mg IV dose, and it is poorly absorbed by mouth. UK label: not recommended (possible bone effects); US: decide on nursing or the drug. LactMed: infant absorption unlikely; withholding feeds for 12-24 h after a dose minimises exposure.
已通報的副作用
- Anemia
- Hypokalemia
- Urinary tract infectious disease
- Hypocalcemia
- Hypomagnesemia
- Hypophosphatemia
禁忌症
- Hypersensitivity to drug, other bisphosphonates, or excipients, including mannitol
哪些人需要特別留意
- Bisphosphonates, such as pamidronate disodium, have been associated with renal toxicity, including focal segmental glomerulosclerosis
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (9)
- Aluminum hydroxide + Pamidronate Moderate
- Dichlorphenamide + Pamidronate Moderate
- Foscarnet + Pamidronate Moderate
- Pamidronate + Tenofovir df Moderate
- Pamidronate + Tenofovir disoproxil Moderate
- Calcium + Pamidronate Minor
- Calcium carbonate + Pamidronate Minor
- Entecavir + Pamidronate Minor
- Pamidronate + Teriparatide Minor
同類別的其他藥品
常見問題
What is Pamidronate used for?
Pamidronate is a medicine in the class musculoskeletal. It is used for Hypercalcemia of malignancy, Osteolytic bone lesions of MM, Osteolytic bone metastases of BC, Paget's disease.
What side effects have been reported with Pamidronate?
Anemia, Hypokalemia, Urinary tract infectious disease, Hypocalcemia, Hypomagnesemia, Hypophosphatemia.
Can Pamidronate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data on fetal risk. Bisphosphonates enter bone and are released over years; in animals pamidronate caused bone mineralisation defects and embryo-fetal effects. UK label: do not use at any stage of pregnancy unless life-threatening hypercalcaemia cannot be controlled otherwise. Breastfeeding: Unknown. Very low milk levels after a 30 mg IV dose, and it is poorly absorbed by mouth. UK label: not recommended (possible bone effects); US: decide on nursing or the drug. LactMed: infant absorption unlikely; withholding feeds for 12-24 h after a dose minimises exposure.
What does Pamidronate interact with?
MediHelp lists 9 known interactions for Pamidronate. Moderate: 5 · Minor: 4. The most serious include Aluminum hydroxide, Dichlorphenamide, Foscarnet.
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