藥物交互作用
Aluminum hydroxide / magnesium trisilicate + Misoprostol
嚴重程度: 中度
Aluminum hydroxide / magnesium trisilicate and Misoprostol: moderate interaction.
最後更新
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摘要
Magnesium-containing antacids can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacids may also modestly lower systemic exposure to misoprostol acid, though the clinical importance of this is uncertain.
用白話說明這項交互作用的意義
Aluminum hydroxide / magnesium trisilicate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
為什麼會發生
Additive osmotic laxative effect of magnesium with misoprostol-induced intestinal secretion and motility, plus possible reduced absorption of the active acid.
處置方式
If an antacid is needed, prefer an aluminum- or calcium-based product without magnesium. Monitor for diarrhea and dehydration, especially in elderly patients.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Misoprostol 的其他交互作用
常見問題
Can I take Aluminum hydroxide / magnesium trisilicate with Misoprostol?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium trisilicate and Misoprostol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids can aggravate the diarrhea that is the most common adverse effect of misoprostol. Antacids may also modestly lower systemic exposure to misoprostol acid, though the clinical importance of this is uncertain.
How serious is the interaction between Aluminum hydroxide / magnesium trisilicate and Misoprostol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid is needed, prefer an aluminum- or calcium-based product without magnesium. Monitor for diarrhea and dehydration, especially in elderly patients.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Oxytocin, Aluminum hydroxide / magnesium carbonate, Citric acid / glucono-delta-lactone / magnesium carbonate. The full list is on the Misoprostol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
