藥物交互作用
Misoprostol + Oxytocin
嚴重程度: 嚴重
Misoprostol and Oxytocin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Misoprostol sensitizes the uterus to oxytocin, and giving oxytocin shortly after misoprostol may cause uterine hyperstimulation. This can lead to fetal distress and, rarely, uterine rupture.
用白話說明這項交互作用的意義
Misoprostol and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Misoprostol belongs to Gastrointestinal Tract; Oxytocin belongs to Endocrine.
為什麼會發生
Additive uterotonic effects through prostaglandin E1 and oxytocin receptor pathways.
處置方式
Delay oxytocin start for at least 4 hours after the last misoprostol dose and monitor uterine activity and fetal heart rate continuously.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Misoprostol 的其他交互作用
Oxytocin 的其他交互作用
常見問題
Can I take Misoprostol with Oxytocin?
MediHelp rates the interaction as major. Misoprostol and Oxytocin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Misoprostol sensitizes the uterus to oxytocin, and giving oxytocin shortly after misoprostol may cause uterine hyperstimulation. This can lead to fetal distress and, rarely, uterine rupture.
How serious is the interaction between Misoprostol and Oxytocin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay oxytocin start for at least 4 hours after the last misoprostol dose and monitor uterine activity and fetal heart rate continuously.
What other medicines interact with Misoprostol?
MediHelp also lists interactions of Misoprostol with, for example, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate, Citric acid / glucono-delta-lactone / magnesium carbonate. The full list is on the Misoprostol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
