藥物交互作用
Alvimopan + Fentanyl
嚴重程度: 禁忌併用
Alvimopan and Fentanyl: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
用白話說明這項交互作用的意義
Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Competitive antagonism of peripheral mu-opioid receptors by alvimopan.
處置方式
Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Fentanyl 的其他交互作用
常見問題
Can I take Alvimopan with Fentanyl?
MediHelp rates the interaction as contraindicated. Alvimopan and Fentanyl are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Alvimopan antagonises peripheral mu-opioid receptors, and patients who have recently taken opioids for more than 7 days are more sensitive to it. This can cause abdominal pain, nausea, vomiting and diarrhea. Short-term perioperative opioid exposure is not expected to cause a significant interaction.
How serious is the interaction between Alvimopan and Fentanyl?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use alvimopan in patients who have had therapeutic opioid doses for more than 7 consecutive days before starting it. Short-term perioperative use is acceptable.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Fentanyl page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
