藥物交互作用
Amifostine + Clonidine
嚴重程度: 嚴重
Amifostine and Clonidine: major interaction.
最後更新
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摘要
Amifostine commonly causes hypotension, and antihypertensives such as clonidine can increase its frequency and severity. At chemotherapy doses this can cause significant hemodynamic compromise.
用白話說明這項交互作用的意義
Amifostine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amifostine belongs to Miscellaneous; Clonidine belongs to Cardiovascular.
為什麼會發生
Additive blood pressure lowering through central sympatholytic action and amifostine-induced hypotension.
處置方式
For chemotherapeutic doses of amifostine, hold clonidine for 24 hours beforehand where safely possible; if it cannot be held, do not give amifostine. Avoid abrupt clonidine withdrawal without a plan for rebound hypertension.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Clonidine 的其他交互作用
Amifostine 的其他交互作用
常見問題
Can I take Amifostine with Clonidine?
MediHelp rates the interaction as major. Amifostine and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amifostine commonly causes hypotension, and antihypertensives such as clonidine can increase its frequency and severity. At chemotherapy doses this can cause significant hemodynamic compromise.
How serious is the interaction between Amifostine and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For chemotherapeutic doses of amifostine, hold clonidine for 24 hours beforehand where safely possible; if it cannot be held, do not give amifostine. Avoid abrupt clonidine withdrawal without a plan for rebound hypertension.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amiodarone, Amoxapine. The full list is on the Clonidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
