藥物交互作用
Betaxolol + Clonidine
嚴重程度: 嚴重
Betaxolol and Clonidine: major interaction.
最後更新
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摘要
Both lower heart rate and blood pressure, so together they can cause marked bradycardia and hypotension. If clonidine is stopped while a beta-blocker continues, rebound hypertension can be exaggerated.
用白話說明這項交互作用的意義
Betaxolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Betaxolol belongs to Cardiovascular; Clonidine belongs to Cardiovascular.
為什麼會發生
Additive effects of central sympatholysis and beta-blockade; unopposed alpha stimulation during clonidine withdrawal on beta-blockade.
處置方式
Monitor heart rate and blood pressure. When stopping, withdraw the beta-blocker several days before gradually tapering clonidine.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Betaxolol 的其他交互作用
Clonidine 的其他交互作用
常見問題
Can I take Betaxolol with Clonidine?
MediHelp rates the interaction as major. Betaxolol and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both lower heart rate and blood pressure, so together they can cause marked bradycardia and hypotension. If clonidine is stopped while a beta-blocker continues, rebound hypertension can be exaggerated.
How serious is the interaction between Betaxolol and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure. When stopping, withdraw the beta-blocker several days before gradually tapering clonidine.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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