藥物交互作用
Atenolol-chlorthalidone + Clonidine
嚴重程度: 嚴重
Atenolol-chlorthalidone and Clonidine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Clonidine lowers heart rate and blood pressure, and atenolol adds to this effect. Importantly, if clonidine is withdrawn while on a beta-blocker, severe rebound hypertension can occur.
用白話說明這項交互作用的意義
Atenolol-chlorthalidone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atenolol-chlorthalidone belongs to Cardiovascular; Clonidine belongs to Cardiovascular.
為什麼會發生
Additive bradycardic and hypotensive effects; beta-blockade leaves unopposed alpha-mediated vasoconstriction during clonidine withdrawal rebound.
處置方式
If both are used, monitor heart rate and blood pressure. To stop therapy, withdraw the beta-blocker gradually first, then taper clonidine several days later.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atenolol-chlorthalidone 的其他交互作用
Clonidine 的其他交互作用
常見問題
Can I take Atenolol-chlorthalidone with Clonidine?
MediHelp rates the interaction as major. Atenolol-chlorthalidone and Clonidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clonidine lowers heart rate and blood pressure, and atenolol adds to this effect. Importantly, if clonidine is withdrawn while on a beta-blocker, severe rebound hypertension can occur.
How serious is the interaction between Atenolol-chlorthalidone and Clonidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If both are used, monitor heart rate and blood pressure. To stop therapy, withdraw the beta-blocker gradually first, then taper clonidine several days later.
What other medicines interact with Atenolol-chlorthalidone?
MediHelp also lists interactions of Atenolol-chlorthalidone with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Atenolol-chlorthalidone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
