藥物交互作用
Amikacin + Atracurium
嚴重程度: 嚴重
Amikacin and Atracurium: major interaction.
最後更新
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摘要
Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
用白話說明這項交互作用的意義
Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amikacin belongs to Anti Bacterial; Atracurium belongs to Musculoskeletal.
為什麼會發生
Aminoglycoside reduction of presynaptic acetylcholine release and postsynaptic sensitivity, additive to nondepolarising blockade.
處置方式
Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Atracurium 的其他交互作用
Amikacin 的其他交互作用
常見問題
Can I take Amikacin with Atracurium?
MediHelp rates the interaction as major. Amikacin and Atracurium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aminoglycosides have intrinsic neuromuscular blocking activity and can potentiate nondepolarising blockers. This can prolong paralysis and delay recovery of spontaneous breathing, with a risk of respiratory depression or apnoea.
How serious is the interaction between Amikacin and Atracurium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and reduce atracurium doses as needed. Ensure ventilatory support is available and recovery is complete before extubation.
What other medicines interact with Atracurium?
MediHelp also lists interactions of Atracurium with, for example, Bacitracin-neomycin-polymyxin, Benzhydrocodone / acetaminophen, Capreomycin. The full list is on the Atracurium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
