藥物交互作用
Atracurium + Bacitracin-neomycin-polymyxin
嚴重程度: 嚴重
Atracurium and Bacitracin-neomycin-polymyxin: major interaction.
最後更新
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摘要
Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
用白話說明這項交互作用的意義
Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atracurium belongs to Musculoskeletal; Bacitracin-neomycin-polymyxin belongs to Anti Bacterial.
為什麼會發生
Polymyxin B and neomycin reduce presynaptic acetylcholine release and postsynaptic sensitivity, adding to non-depolarizing neuromuscular blockade.
處置方式
Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Bacitracin-neomycin-polymyxin 的其他交互作用
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin 嚴重
- Bacitracin-neomycin-polymyxin + Capreomycin 嚴重
- Bacitracin-neomycin-polymyxin + Cidofovir 嚴重
- Bacitracin-neomycin-polymyxin + Cisatracurium 嚴重
- Bacitracin-neomycin-polymyxin + Pancuronium 嚴重
- Bacitracin-neomycin-polymyxin + Rocuronium 嚴重
Atracurium 的其他交互作用
常見問題
Can I take Atracurium with Bacitracin-neomycin-polymyxin?
MediHelp rates the interaction as major. Atracurium and Bacitracin-neomycin-polymyxin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemically absorbed polymyxin B and neomycin can have neuromuscular blocking activity and may potentiate non-depolarizing blockers. This could cause prolonged paralysis and respiratory depression. The risk with topical or irrigation use is low unless there is significant absorption from large wounds, body cavities or irrigation.
How serious is the interaction between Atracurium and Bacitracin-neomycin-polymyxin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid peritoneal or wound irrigation with these antibiotics around anesthesia where possible. Monitor neuromuscular function and be prepared for ventilatory support, noting that calcium may be needed for reversal.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Capreomycin, Cidofovir. The full list is on the Bacitracin-neomycin-polymyxin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
