藥物交互作用
Amikacin + Ceftazidime
嚴重程度: 中度
Amikacin and Ceftazidime: moderate interaction.
最後更新 來源: US FDA label
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摘要
Amikacin is nephrotoxic, and ceftazidime has been reported to add to renal injury when given with aminoglycosides. Cephalosporins alone are rarely nephrotoxic, so the additive risk is modest and mainly relevant with high aminoglycoside exposure, prolonged courses or existing renal impairment. The combination is commonly used deliberately for serious Gram-negative infections.
用白話說明這項交互作用的意義
Amikacin and Ceftazidime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Ceftazidime belongs to Anti Bacterial.
為什麼會發生
Aminoglycosides accumulate in proximal tubular cells and cause tubular injury; cephalosporins may contribute additional tubular stress, though the mechanism is not clearly established.
處置方式
Use the combination when clinically indicated and dose both drugs for renal function. Monitor serum creatinine and urine output at baseline and at least two to three times weekly, and use amikacin therapeutic drug monitoring to keep troughs low.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
參考資料
Amikacin 的其他交互作用
Ceftazidime 的其他交互作用
常見問題
Can I take Amikacin with Ceftazidime?
MediHelp rates the interaction as moderate. Amikacin and Ceftazidime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amikacin is nephrotoxic, and ceftazidime has been reported to add to renal injury when given with aminoglycosides. Cephalosporins alone are rarely nephrotoxic, so the additive risk is modest and mainly relevant with high aminoglycoside exposure, prolonged courses or existing renal impairment. The combination is commonly used deliberately for serious Gram-negative infections.
How serious is the interaction between Amikacin and Ceftazidime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the combination when clinically indicated and dose both drugs for renal function. Monitor serum creatinine and urine output at baseline and at least two to three times weekly, and use amikacin therapeutic drug monitoring to keep troughs low.
What other medicines interact with Amikacin?
MediHelp also lists interactions of Amikacin with, for example, Cidofovir, Adefovir, Amphotericin b. The full list is on the Amikacin page.
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