藥物交互作用
Amiodarone + Betaxolol
嚴重程度: 嚴重
Amiodarone and Betaxolol: major interaction.
最後更新
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摘要
Both drugs slow sinus rate and AV conduction, and combining them can cause marked bradycardia, AV block or sinus arrest. The risk is highest in patients with existing conduction disease or at initiation.
用白話說明這項交互作用的意義
Amiodarone and Betaxolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Betaxolol belongs to Cardiovascular.
為什麼會發生
Additive negative chronotropic and dromotropic effects, with amiodarone's beta-blocking and calcium-channel-like actions adding to beta-1 blockade.
處置方式
Monitor ECG and heart rate closely when starting the combination and reduce the betaxolol dose if bradycardia occurs. Avoid in patients with significant conduction disease unless a pacemaker is in place.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Betaxolol 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Betaxolol?
MediHelp rates the interaction as major. Amiodarone and Betaxolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs slow sinus rate and AV conduction, and combining them can cause marked bradycardia, AV block or sinus arrest. The risk is highest in patients with existing conduction disease or at initiation.
How serious is the interaction between Amiodarone and Betaxolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate closely when starting the combination and reduce the betaxolol dose if bradycardia occurs. Avoid in patients with significant conduction disease unless a pacemaker is in place.
What other medicines interact with Betaxolol?
MediHelp also lists interactions of Betaxolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Betaxolol page.
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