藥物交互作用
Amiodarone + Amisulpride
嚴重程度: 禁忌併用
Amiodarone and Amisulpride: contraindicated interaction.
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摘要
Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
用白話說明這項交互作用的意義
Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amiodarone belongs to Cardiovascular; Amisulpride belongs to Central Nervous System.
為什麼會發生
Additive QT prolongation through blockade of cardiac potassium channels (pharmacodynamic).
處置方式
Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amiodarone 的其他交互作用
Amisulpride 的其他交互作用
常見問題
Can I take Amiodarone with Amisulpride?
MediHelp rates the interaction as contraindicated. Amiodarone and Amisulpride are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, and their combination substantially increases the risk of torsades de pointes. Amiodarone's long half-life means the risk persists after it is stopped.
How serious is the interaction between Amiodarone and Amisulpride?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with lower QT liability. If it cannot be avoided, use continuous ECG monitoring and keep potassium and magnesium normal.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
