藥物交互作用
Amiodarone + Granisetron
嚴重程度: 嚴重
Amiodarone and Granisetron: major interaction.
最後更新
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摘要
Amiodarone markedly prolongs the QT interval and granisetron has a smaller QT effect. Together they can add to the risk of torsades de pointes.
用白話說明這項交互作用的意義
Amiodarone and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Granisetron belongs to Gastrointestinal Tract.
為什麼會發生
Additive QT prolongation through blockade of cardiac repolarizing currents.
處置方式
Use a non-QT-prolonging antiemetic if possible. If used together, correct potassium and magnesium and monitor the ECG.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Granisetron 的其他交互作用
Amiodarone 的其他交互作用
常見問題
Can I take Amiodarone with Granisetron?
MediHelp rates the interaction as major. Amiodarone and Granisetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone markedly prolongs the QT interval and granisetron has a smaller QT effect. Together they can add to the risk of torsades de pointes.
How serious is the interaction between Amiodarone and Granisetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiemetic if possible. If used together, correct potassium and magnesium and monitor the ECG.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amisulpride, Arsenic trioxide. The full list is on the Granisetron page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
