藥物交互作用
Amitriptyline + Isocarboxazid
嚴重程度: 禁忌併用
Amitriptyline and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Amitriptyline blocks reuptake of serotonin and noradrenaline while isocarboxazid stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
用白話說明這項交互作用的意義
Amitriptyline and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amitriptyline belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.
為什麼會發生
MAO inhibition combined with monoamine reuptake inhibition causes excess synaptic serotonin and noradrenaline
處置方式
Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amitriptyline 的其他交互作用
Isocarboxazid 的其他交互作用
常見問題
Can I take Amitriptyline with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amitriptyline and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Amitriptyline blocks reuptake of serotonin and noradrenaline while isocarboxazid stops their breakdown. Together they can precipitate serotonin syndrome or a hypertensive crisis.
How serious is the interaction between Amitriptyline and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated; allow at least 14 days after stopping an irreversible MAOI before starting amitriptyline (and 2 weeks the other way around).
What other medicines interact with Amitriptyline?
MediHelp also lists interactions of Amitriptyline with, for example, Methylene blue, Phenelzine, Pimozide. The full list is on the Amitriptyline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
