藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Dofetilide
嚴重程度: 禁忌併用
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide: contraindicated interaction.
最後更新
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摘要
Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
為什麼會發生
Thiazide-related reduction in renal elimination of dofetilide, with electrolyte disturbances adding to QT prolongation.
處置方式
Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Dofetilide 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Dofetilide?
MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Dofetilide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydrochlorothiazide can raise dofetilide levels through reduced renal clearance and may also cause hypokalemia or hypomagnesemia. Higher dofetilide exposure prolongs the QT interval and can provoke torsades de pointes.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Dofetilide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use as labeled for dofetilide with thiazides; use an alternative antihypertensive. If therapy is essential, monitor QTc, potassium and magnesium closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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