藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Sparsentan
嚴重程度: 禁忌併用
Amlodipine-hydrochlorothiazide-valsartan and Sparsentan: contraindicated interaction.
最後更新
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摘要
Sparsentan blocks the angiotensin II receptor in addition to endothelin receptors, so adding valsartan duplicates the effect. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
為什麼會發生
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
處置方式
Do not combine; stop the ARB-containing product before starting sparsentan and use another agent for blood pressure control if needed.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Sparsentan 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Sparsentan?
MediHelp rates the interaction as contraindicated. Amlodipine-hydrochlorothiazide-valsartan and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan blocks the angiotensin II receptor in addition to endothelin receptors, so adding valsartan duplicates the effect. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB-containing product before starting sparsentan and use another agent for blood pressure control if needed.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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