藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Lisinopril
嚴重程度: 嚴重
Amlodipine-hydrochlorothiazide-valsartan and Lisinopril: major interaction.
最後更新
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摘要
Lisinopril with valsartan produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and declining renal function, particularly in diabetes or kidney disease.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system by an ACE inhibitor and an angiotensin receptor blocker.
處置方式
Avoid the combination and use one renin-angiotensin agent. If both are continued, check potassium and creatinine regularly and monitor blood pressure.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Lisinopril 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lisinopril?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lisinopril with valsartan produces dual renin-angiotensin system blockade. This raises the risk of hypotension, hyperkalemia and declining renal function, particularly in diabetes or kidney disease.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use one renin-angiotensin agent. If both are continued, check potassium and creatinine regularly and monitor blood pressure.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
