藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Benazepril
嚴重程度: 嚴重
Amlodipine-olmesartan-hydrochlorothiazide and Benazepril: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
為什麼會發生
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two sites, which reduces glomerular filtration pressure and aldosterone-mediated potassium excretion.
處置方式
Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Benazepril 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Benazepril?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an angiotensin receptor blocker with an ACE inhibitor produces dual blockade of the renin-angiotensin system. This raises the risk of hypotension, hyperkalemia and acute kidney injury, and outcome trials showed no cardiovascular benefit over a single agent in most patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Benazepril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use only one RAS blocker. If it is unavoidable, monitor serum potassium, creatinine and blood pressure closely.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
