藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan
嚴重程度: 禁忌併用
Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan: contraindicated interaction.
最後更新
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摘要
Sparsentan also blocks the angiotensin II receptor, so adding olmesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Sparsentan belongs to Genitourinary.
為什麼會發生
Additive pharmacodynamic angiotensin II type 1 receptor blockade.
處置方式
Do not combine; stop the ARB-containing product before starting sparsentan.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amiloride + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Sparsentan 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Sparsentan?
MediHelp rates the interaction as contraindicated. Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sparsentan also blocks the angiotensin II receptor, so adding olmesartan duplicates this action. This raises the risk of hypotension, syncope, hyperkalemia and acute kidney injury.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Sparsentan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop the ARB-containing product before starting sparsentan.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Acemetacin. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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