藥物交互作用
Benazepril + Sacubitril / valsartan
嚴重程度: 禁忌併用
Benazepril and Sacubitril / valsartan: contraindicated interaction.
最後更新
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摘要
Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
用白話說明這項交互作用的意義
Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Combined inhibition of neprilysin and ACE causes bradykinin accumulation, with added renin-angiotensin blockade from valsartan.
處置方式
Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Benazepril 的其他交互作用
常見問題
Can I take Benazepril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
How serious is the interaction between Benazepril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril-valsartan, Amifostine. The full list is on the Benazepril page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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