藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Etodolac
嚴重程度: 嚴重
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac: major interaction.
最後更新 來源: US FDA label
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摘要
NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
為什麼會發生
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, antagonizing antihypertensive effects and impairing renal function.
處置方式
Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Etodolac 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Etodolac?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
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