藥物交互作用
Amobarbital + Desogestrel-ethinyl estradiol
嚴重程度: 嚴重
Amobarbital and Desogestrel-ethinyl estradiol: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Barbiturates induce hepatic enzymes and can speed up the metabolism of both ethinyl estradiol and desogestrel's active metabolite. This lowers hormone levels and may cause breakthrough bleeding and contraceptive failure.
用白話說明這項交互作用的意義
Amobarbital and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Desogestrel-ethinyl estradiol belongs to Endocrine.
為什麼會發生
Induction of CYP3A4 and other hepatic enzymes increasing clearance of contraceptive steroids.
處置方式
Use an alternative non-hormonal or non-enzyme-dependent contraceptive method, such as a copper IUD or DMPA. Continue backup measures for several weeks after stopping the barbiturate.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Desogestrel-ethinyl estradiol 的其他交互作用
Amobarbital 的其他交互作用
常見問題
Can I take Amobarbital with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Amobarbital and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce hepatic enzymes and can speed up the metabolism of both ethinyl estradiol and desogestrel's active metabolite. This lowers hormone levels and may cause breakthrough bleeding and contraceptive failure.
How serious is the interaction between Amobarbital and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative non-hormonal or non-enzyme-dependent contraceptive method, such as a copper IUD or DMPA. Continue backup measures for several weeks after stopping the barbiturate.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Anastrozole. The full list is on the Desogestrel-ethinyl estradiol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
