藥物交互作用
Desogestrel-ethinyl estradiol + Fezolinetant
嚴重程度: 禁忌併用
Desogestrel-ethinyl estradiol and Fezolinetant: contraindicated interaction.
最後更新
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摘要
Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
用白話說明這項交互作用的意義
Desogestrel-ethinyl estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desogestrel-ethinyl estradiol belongs to Endocrine; Fezolinetant belongs to Endocrine.
為什麼會發生
Ethinyl estradiol inhibits CYP1A2, reducing fezolinetant metabolism and increasing its plasma concentration.
處置方式
Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Desogestrel-ethinyl estradiol 的其他交互作用
Fezolinetant 的其他交互作用
常見問題
Can I take Desogestrel-ethinyl estradiol with Fezolinetant?
MediHelp rates the interaction as contraindicated. Desogestrel-ethinyl estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
How serious is the interaction between Desogestrel-ethinyl estradiol and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Aminocaproic acid, Amobarbital, Anastrozole. The full list is on the Desogestrel-ethinyl estradiol page.
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