藥物交互作用
Amobarbital + Lenacapavir
嚴重程度: 嚴重
Amobarbital and Lenacapavir: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Amobarbital may markedly reduce lenacapavir levels through CYP3A4 induction. Subtherapeutic antiviral exposure risks virologic failure and resistance.
用白話說明這項交互作用的意義
Amobarbital and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Lenacapavir belongs to Anti Virals.
為什麼會發生
Induction of CYP3A4 (and likely P-gp/UGT1A1) increases lenacapavir clearance.
處置方式
Avoid the combination and use a non-inducing alternative to amobarbital. Monitor HIV viral load if exposure cannot be avoided.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amobarbital 的其他交互作用
Lenacapavir 的其他交互作用
常見問題
Can I take Amobarbital with Lenacapavir?
MediHelp rates the interaction as major. Amobarbital and Lenacapavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may markedly reduce lenacapavir levels through CYP3A4 induction. Subtherapeutic antiviral exposure risks virologic failure and resistance.
How serious is the interaction between Amobarbital and Lenacapavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative to amobarbital. Monitor HIV viral load if exposure cannot be avoided.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
