藥物交互作用
Lenacapavir + Rifampicin
嚴重程度: 禁忌併用
Lenacapavir and Rifampicin: contraindicated interaction.
最後更新
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摘要
Rifampicin substantially lowers lenacapavir concentrations. Subtherapeutic levels may cause loss of virologic suppression and selection of resistance.
用白話說明這項交互作用的意義
Lenacapavir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lenacapavir belongs to Anti Virals; Rifampicin belongs to Anti Bacterial.
為什麼會發生
Rifampicin is a strong inducer of CYP3A and P-gp, increasing lenacapavir clearance.
處置方式
Do not coadminister. Use an alternative antimycobacterial such as rifabutin only after checking current labeling, or select another HIV regimen.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Lenacapavir 的其他交互作用
Rifampicin 的其他交互作用
常見問題
Can I take Lenacapavir with Rifampicin?
MediHelp rates the interaction as contraindicated. Lenacapavir and Rifampicin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifampicin substantially lowers lenacapavir concentrations. Subtherapeutic levels may cause loss of virologic suppression and selection of resistance.
How serious is the interaction between Lenacapavir and Rifampicin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Use an alternative antimycobacterial such as rifabutin only after checking current labeling, or select another HIV regimen.
What other medicines interact with Lenacapavir?
MediHelp also lists interactions of Lenacapavir with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Lenacapavir page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
