藥物交互作用
Amoxapine + Isocarboxazid
嚴重程度: 禁忌併用
Amoxapine and Isocarboxazid: contraindicated interaction.
最後更新
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摘要
Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
用白話說明這項交互作用的意義
Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition combined with amoxapine's reuptake inhibition of norepinephrine and serotonin leads to excess monoamine activity.
處置方式
Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Isocarboxazid 的其他交互作用
常見問題
Can I take Amoxapine with Isocarboxazid?
MediHelp rates the interaction as contraindicated. Amoxapine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAOI with amoxapine can produce serotonin syndrome and hypertensive reactions. Labeling prohibits concurrent use of MAOIs and tricyclic-type antidepressants.
How serious is the interaction between Amoxapine and Isocarboxazid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow a washout of at least 14 days after stopping isocarboxazid before starting amoxapine, and an adequate washout in the other direction.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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