藥物交互作用
Amoxapine + Safinamide
嚴重程度: 禁忌併用
Amoxapine and Safinamide: contraindicated interaction.
最後更新
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摘要
Safinamide is contraindicated with tricyclic and related antidepressants such as amoxapine due to the risk of serotonin syndrome. Severe cases can be life threatening.
用白話說明這項交互作用的意義
Amoxapine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Amoxapine inhibits serotonin and norepinephrine reuptake, adding to monoamine accumulation from MAO-B inhibition.
處置方式
Avoid the combination per safinamide labeling. If a switch is made, allow an adequate washout and monitor for serotonergic signs.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Safinamide 的其他交互作用
常見問題
Can I take Amoxapine with Safinamide?
MediHelp rates the interaction as contraindicated. Amoxapine and Safinamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Safinamide is contraindicated with tricyclic and related antidepressants such as amoxapine due to the risk of serotonin syndrome. Severe cases can be life threatening.
How serious is the interaction between Amoxapine and Safinamide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination per safinamide labeling. If a switch is made, allow an adequate washout and monitor for serotonergic signs.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amphetamine polistirex, Clomipramine. The full list is on the Safinamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
