藥品參考
Safinamide
Safinamide is a medicine in the class central nervous system. It is used for parkinson disease.
- 藥物類別: Central Nervous System
- 用途: parkinson disease
最後更新
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本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Central Nervous System
- 常見劑型
- 錠劑
- 常見規格
- 50 mg, 100 mg
- 已知交互作用
- 156 (禁忌併用: 48 · 嚴重: 34 · 中度: 36 · 輕微: 38)
- 商品名
- 8
- 國家與市場
- 4
用途
作用方式
Inhibition of MAO-B activity, by blocking the catabolism of dopamine, is thought to result in an increase in dopamine levels and a subsequent increase in dopaminergic activity in the brain The precise mechanism by which safinamide exerts its effect in PD is unknown
成人常用劑量（仿單摘要）
Initial: 50 mg PO qDay
懷孕與哺乳
- 懷孕
- Unsafe No adequate human data. US label: in animals it caused developmental toxicity, including birth defects, at clinically relevant doses, and at lower doses with levodopa/carbidopa. EU label: not recommended in pregnancy; women who could become pregnant need contraception.
- 哺乳
- Unknown No human milk data; it passes into rat milk and caused liver toxicity in nursing rat pups. EU label: should not be used while breastfeeding; US label: weigh benefits. LactMed: alternative agents are preferred.
已通報的副作用
- Nausea
- Insomnia
- Orthostatic hypotension
- Hypertension
- Dyskinesia
- ALT or AST increased to >ULN
哪些人需要特別留意
- May cause hallucinations and psychotic behavior; consider dosage reduction or stopping medication if patient develops hallucinations while on therapy
- May cause problems with impulse control/compulsive behaviors; consider dose reduction or stopping medication if a patient develops compulsive behavior while on therapy
- May cause withdrawal-emergent hyperpyrexia and confusion
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (156)
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
同類別的其他藥品
常見問題
What is Safinamide used for?
Safinamide is a medicine in the class central nervous system. It is used for Parkinson disease.
What side effects have been reported with Safinamide?
Nausea, Insomnia, Orthostatic hypotension, Hypertension, Dyskinesia, ALT or AST increased to >ULN.
Can Safinamide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No adequate human data. US label: in animals it caused developmental toxicity, including birth defects, at clinically relevant doses, and at lower doses with levodopa/carbidopa. EU label: not recommended in pregnancy; women who could become pregnant need contraception. Breastfeeding: Unknown. No human milk data; it passes into rat milk and caused liver toxicity in nursing rat pups. EU label: should not be used while breastfeeding; US label: weigh benefits. LactMed: alternative agents are preferred.
What does Safinamide interact with?
MediHelp lists 156 known interactions for Safinamide. Contraindicated: 48 · Major: 34 · Moderate: 36 · Minor: 38. The most serious include Amitriptyline, Amoxapine, Amphetamine polistirex.
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