藥物交互作用
Amoxapine + Selegiline
嚴重程度: 禁忌併用
Amoxapine and Selegiline: contraindicated interaction.
最後更新
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摘要
Selegiline is a MAO-B inhibitor that loses selectivity at higher doses and, together with a tricyclic-type antidepressant such as amoxapine, can precipitate serotonin syndrome or hypertensive reactions. Labeling for both drug classes advises against concurrent use.
用白話說明這項交互作用的意義
Amoxapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Combined MAO inhibition and inhibition of norepinephrine and serotonin reuptake, causing excess monoaminergic activity.
處置方式
Do not co-administer; allow at least 14 days between stopping selegiline and starting amoxapine, and an adequate washout in the other direction. Seek urgent care for agitation, hyperthermia, tremor or severe hypertension.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Selegiline 的其他交互作用
常見問題
Can I take Amoxapine with Selegiline?
MediHelp rates the interaction as contraindicated. Amoxapine and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is a MAO-B inhibitor that loses selectivity at higher doses and, together with a tricyclic-type antidepressant such as amoxapine, can precipitate serotonin syndrome or hypertensive reactions. Labeling for both drug classes advises against concurrent use.
How serious is the interaction between Amoxapine and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping selegiline and starting amoxapine, and an adequate washout in the other direction. Seek urgent care for agitation, hyperthermia, tremor or severe hypertension.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Atomoxetine, Benzphetamine. The full list is on the Selegiline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
