藥物交互作用
Buprenorphine long-acting + Selegiline
嚴重程度: 禁忌併用
Buprenorphine long-acting and Selegiline: contraindicated interaction.
最後更新
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摘要
Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
用白話說明這項交互作用的意義
Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
MAO inhibition combined with serotonergic opioid activity increases serotonin, and MAO inhibitors may also potentiate opioid effects.
處置方式
Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Selegiline 的其他交互作用
常見問題
Can I take Buprenorphine long-acting with Selegiline?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Concurrent use may cause serotonin syndrome or opioid toxicity such as respiratory depression and coma. Long-acting buprenorphine cannot be quickly withdrawn, which makes any reaction harder to manage.
How serious is the interaction between Buprenorphine long-acting and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use long-acting buprenorphine in patients taking an MAO inhibitor or within 14 days of stopping one. Choose a non-serotonergic alternative.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
