藥物交互作用
Amphotericin b deoxycholate + Cidofovir
嚴重程度: 禁忌併用
Amphotericin b deoxycholate and Cidofovir: contraindicated interaction.
最後更新
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摘要
Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.
用白話說明這項交互作用的意義
Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
Additive nephrotoxicity: cidofovir causes proximal tubular injury and amphotericin B causes tubular toxicity and renal vasoconstriction.
處置方式
Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Cidofovir 的其他交互作用
常見問題
Can I take Amphotericin b deoxycholate with Cidofovir?
MediHelp rates the interaction as contraindicated. Amphotericin b deoxycholate and Cidofovir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs injure the kidney, and their combined use can cause acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its labeling prohibits concomitant nephrotoxic agents.
How serious is the interaction between Amphotericin b deoxycholate and Cidofovir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; stop amphotericin at least 7 days before cidofovir where possible and choose an alternative agent. Monitor serum creatinine and urine protein before each cidofovir dose.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b, Bacitracin. The full list is on the Cidofovir page.
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